Best Weed Killer

Using a weed killer to get rid of resilient weeds is inevitable, particularly when a popular organic solution or homemade weed killer recipe just can’t get the job done. But while weed killers have a high success rate, you may do more harm than good to your garden if you fail to choose a weed killer that’s specific to your requirements.

With this in mind, we tried and tested a myriad of weed killer options recommended by professional gardeners and seasoned home gardening professionals to bring you a roundup of the best weed killer options.

Our Top Picks for The Best Weed Killer

Overall Best Weed Killer: Compare-N-Save Concentrate Grass and Weed Killer, 41% Glyphosate

Compare-N-Save Concentrate Grass and Weed Killer, 41-Percent Glyphosate, 1-Gallon , White - 016869
4,266 Reviews
Compare-N-Save Concentrate Grass and Weed Killer, 41-Percent Glyphosate, 1-Gallon , White - 016869
  • Rainproof in 2 hours
  • Visible results in as little as 2 to 4 days
  • Contains 41-percent glyphosate
  • Covers over 25,000 square feet
  • Makes up to 85 gal. of ready-to-use spray. Note: Packaging may vary

Reasons to Buy

  • Contains 41% Glyphosate
  • Noticeable Results in just 2 to 4 days
  • Rainproof in as little as 2 hours
  • Can treat more than 25,000sqft
  • Ready-to-Use

If getting rid of every single weed pestering your garden or lawn is your goal, look no further than the Compare-N-Save Concentrate Grass and Weed Killer with 41% Glyphosate. Our overall best weed killer pick does not discriminate when it comes to weeds and will annihilate everything in its path. Its strength comes from the 41% glyphosate that functions to prevent weeds from producing proteins required for growth.

Following application, expect pesky weeds to die in just a week or two. This weed and grass killer can even eradicate the toughest of weeds, including the hardiest perennial and annual weeds. Used correctly, you can even use it relatively near edible plants.

Runner-Up for Best Weed Killer: RM43 43% Glyphosate Plus Weed Preventer Total Vegetation Control

Reasons to Buy

  • Kills weeds and prevents their return for as long as 1 year
  • Potent 43% Glyphosate and Imazapyr Formula
  • Covers approximately 17,297sqft
  • Perfect for parking areas, driveways, sidewalks, gravel paths, fencerows, and around barns or farm structures

The RM43 Weed Preventer and Killer is an ideal solution for effective vegetation control around farm structures, parking spaces, driveways, sidewalks, gravel pathways, fencerows, and such. It’s highly capable of killing grasses and weeds and preventing new ones from cropping up for up to one year. Its concentrated 43% Glyphosate and Imazapyr formula is extremely effective against a plethora of weeds, brush, vines, and grasses.

Because of RM43’s immensely potent formula, spot treatment is necessary if you don’t want your other plants to suffer the same fate as the undesirable weeds. For total control of your vegetation, apply on bare ground and experience this weed killer’s powerful effects.

Best Natural and Organic Weed Killer: Green Gobbler Vinegar Weed Killer

Green Gobbler Vinegar Weed & Grass Killer | Natural and Organic Weed & Grass Killer | Pet Safe | 1 Gallon
1,461 Reviews
Green Gobbler Vinegar Weed & Grass Killer | Natural and Organic Weed & Grass Killer | Pet Safe | 1 Gallon
  • KILLS WEEDS & GRASS FAST - Eliminate any type of weed in just a matter of hours. Expect full desiccation in less than 24 hours. Green Gobbler contains 20% acetic acid. Use on crabgrass, dandelions, clover weeds, white clover, moss, etc.
  • SAFE TO USE ANYWHERE - Perfect for residential, commercial, industrial and agricultural use. Apply where weeds and grasses are not desired. Use on driveways, sidewalks, concrete, mulch beds, pavers, flower beds, parking lots, farmlands, barns, etc. Ready to use right out the container.
  • CERTIFIED FOR ORGANIC USE - Completely eliminates and desiccates weeds and grasses without using toxic chemicals. Made straight from corn. OMRI listed weed killer and certified for organic use.
  • POWERFUL FORMULA - NO potentially cancer-causing chemicals. Glyphosate-free. 20% formula is four times stronger than traditional table vinegar. Made strictly from ethanol distilled from corn grain.
  • 30-DAY MONEY BACK GUARANTEE - If you are not pleased, call or email us with your order number and we will reimburse your entire purchase. We value our customers and we stand behind all of our products. Expect a refund with no questions asked.

Reasons to Buy

  • Eradicate many different types of weeds in just a couple of hours
  • Safe for use anywhere in your garden
  • Certified Organic—Manufactured from ethanol derived from corn grain, OMRI-approved
  • Potent 20% Vinegar Formula that’s 4X more effective than the typical table vinegar

The Green Gobbler 20% Vinegar Weed Killer is the easiest and quickest way to kill all sorts of weeds in your garden. This powerful weed killer is sourced from corn grain, certified organic, and approved by the OMRI so you won’t have to deal with potentially harmful chemicals.

It is extremely effective at killing many different broadleaf weeds such as crabgrass, musk thistle, white clover, chickweed, and oxalis among many others. And yes—it is likewise an immensely potent dandelion killer. Likewise, you can use the Green Gobbler along fences, between pavers, and near foundations.

Best Weed Preventer: Preen Extended Control Weed Preventer

Preen 246422 Extended Control Weed Preventer - 13.75 lb. - Covers 2,245 sq. ft.
336 Reviews
Preen 246422 Extended Control Weed Preventer - 13.75 lb. - Covers 2,245 sq. ft.
  • 1 application blocks weeds up to 6 months
  • When used as directed Preen Extended Control Weed Preventer can be used around more than 600 perennials, groundcovers, shrubs and trees as listed on the product label
  • Applicator scoop included
  • Not intended for use on flower seeds, lawns, vegetable gardens, water gardens or other food-producing or edible plants
  • Not available for sale in NY
  • Covers 2, 245 sq. Ft.

Reasons to Buy

  • Prevents Weed Growth for as long as 6 months
  • Treats up to 2,245sqft
  • Trusted Gardening Brand
  • Used correctly, it can be utilized around over 600 shrubs, perennials, trees, and groundcovers

As its name suggests, the Preen Extended Control Weed Preventer halts weed growth from the source for as long as six months by preventing their germination. Basically, it efficiently deals with potential weed issues—before they even crop up. Overall, it’s an ideal weed killer wingman to established gardens and lawns.

For example, you already have a garden full of flowers, fruit trees, and vegetables and you don’t need pesky weeds overrunning them. This Preen weed control product is capable of preventing the growth of 27 grass and broadleaf weed types. Plus, it is friendly to more than 200 kinds of veggies, flowers, trees, shrubs, and bulbs.

Best Weed Killer for Creeping Charlie: Southern AG CROSSBOW32 Weed & Brush Killer

Southern Ag CROSSBOW32 Weed & Brush Killer, 32oz-1 Quart Crossbow Specialty Herbicide 2 4 D & Triclopyr Weed & Brus, (s) (32 oz)
561 Reviews
Southern Ag CROSSBOW32 Weed & Brush Killer, 32oz-1 Quart Crossbow Specialty Herbicide 2 4 D & Triclopyr Weed & Brus, (s) (32 oz)
  • Size: 1 Quart
  • Controls most unwanted trees and brush.
  • Use on rangeland, grass pastures, non-crop areas.
  • CONTAINS: 2,4-dichlorophenoxyacetic acid, butoxyethyl ester, Triclopyr
  • For large quantity discount consideration or to request a mixed multi-pack, please message us.

Reasons to Buy

  • Kills Woody Plants and Brush
  • Excellent Control of Creeping Charlie
  • Doesn’t Affect Healthy, Established Grass
  • Rainproof in a little as 2 hours

Aside from being extremely effective against the dreaded creeping Charlie, also called ground ivy, the Southern AG Crossbow32 Weed and Brush Killer is likewise effective against various types of invasive weeds, brushes, and trees. It’s perfect for killing perennial and annual broadleaf weeds on grass pastures, rangeland, non-irrigation ditch banks, fencerows, industrial sites, and non-crop areas.

According to most reviews, this Crossbow herbicide is best used during your target weed’s peak-grow cycle, during a dry, cool, and sunny day for the best possible results.

Best Weed Killer for Hard Surfaces: Ortho GroundClear Vegetation Killer Concentrate

Ortho GroundClear Vegetation Killer Concentrate2, 2 gal.
582 Reviews
Ortho GroundClear Vegetation Killer Concentrate2, 2 gal.
  • Kills and prevents weeds for up to 1 year
  • Visible results in 6 hours
  • Treats 5x more area (when compared to previous formula)
  • Apply to driveways; sidewalks; fence lines; patios and gravel areas
  • Kills weeds and grasses to the root

Reasons to Buy

  • Eliminate and Prevent Weed Growth for as long as 1 year
  • Covers 5x more surface area than its previous formulation
  • Noticeable Effects in just 6 hours
  • Targets Grasses and Weeds in the roots
  • Ideal for gravel areas, fence lines, patios, sidewalks, and driveways

The Ortho GroundClear Vegetation Killer Concentrate features a powerful non-selective herbicide formula that will eradicate all kinds of post-emergent and pre-emergent vegetation. You will experience fairly fast results as it penetrates the weed’s root system, killing it at the core.

The Ortho Ground Clear formula boasts of Imazapyr and Glyphosate, which are systemic, non-selective chemicals found to be immensely efficient at preventing and killing all sorts of weeds. In addition, expect the treated weeds to not reappear for as long as one year.

Best Weed Killer and Preventer: Roundup Extended Control Grass and Weed Killer and Preventer

Reasons to Buy

  • Destroys existing weeds at the root and prevents their regrowth for as long as 4 months
  • Obvious results in just 3 hours
  • Rainproof in as little as 10 minutes
  • Very easy-to-use pump and sprayer

The Roundup Extended Control Grass and Weed Killer and Preventer offers an innovative Pump ‘N Go sprayer design for easy application of its ready-to-use, premixed formula. Rainproof in as little as 10 minutes, you can spot visible effects in under 3 hours, and expect its effects to last for as long as four months. This weed killer is easily absorbed via the leaves of the weeds and is carried to the root system to ultimately kill the weeds.

It’s important to note that this is not your standard Roundup for lawns—it’s best used in walkways, patios, gravel areas, driveways, mulched beds, along foundations and fence lines, as well as around tree rings. If you are looking for a premixed herbicide that won’t require any preparation at all, this one’s for you. Instead of a Roundup concentrate, you get a premixed formula with a handy sprayer, so you won’t have to mix and measure anything! Once you receive the product, provided that it’s a suitable day for application, you can start using right away.

Best Brush Killer: BioAdvanced Brush Killer Plus

BioAdvanced 704640B 704640 Brush Killer, 32-Ounce, Concentrate
549 Reviews
BioAdvanced 704640B 704640 Brush Killer, 32-Ounce, Concentrate
  • Special penetrating formula, kills even the toughest plants
  • Kills kudzu, poison ivy, poison oak, blackberry and bramble
  • Plus kills 70+ Other types of listed weeds and brush
  • Even kills stumps
  • 2x more coverage than the leading brand
  • Makes up to 8 gallons
  • 32 oz Concentrate treats up to 4, 000 sq. Ft
  • Kills tough brush - roots and all
  • Kills poison ivy, poison oak, wild berries, kudzu and 67 other types of weeds and brush
  • Now in convenient, no-mix formula

Reasons to Buy

  • Specially-Formulated Brush Killer Formula
  • Kills more than 70 kinds of Brushes and Weeds
  • Highly Effective at Killing Stumps
  • Makes 8 gallons that can treat up to 4,000sqft

With just one application, you can expect the BiodAdvanced Brush Killer Plus to get rid of kudzu, poison oak, poison ivy, bramble, blackberry, and other extra-resilient brushes down to their hardy roots. This potent systemic and selective brush killer enters tough brushes through their leaves and roots to efficiently snuff them out. It is so tough that it’s even capable of killing stumps. Expect to see evident symptoms of plant death such as yellowing and wilting as early as one week after application. 

Best for Weed and Feed: Spectracide Weed and Feed 20-0-0

Spectracide Weed & Feed 20-0-0, Ready-to-Spray, 32-Ounce
577 Reviews
Spectracide Weed & Feed 20-0-0, Ready-to-Spray, 32-Ounce
  • DUAL-ACTION FORMULA: Kills major broadleaf weeds while feeding your lawn
  • FEEDS LAWN: Fertilizes with 20 percent nitrogen formulation
  • KILLS WEEDS: Controls dandelion, chickweed, knotweed, plantain, clover, mallow, purslane and many broadleaf weeds as listed
  • QUICKFLIP SPRAYER: Just connect to your hose and spray – just grip, flip and go

Reasons to Buy

  • Strong Dual-Action Formula that kills resilient weeds and feeds your garden
  • Fertilizes your garden with 20% nitrogen
  • Covers as much as 7,500sqft
  • QuickFlip Sprayer—designed to connect to the spray and hose for easy application

The Spectracide Weed and Feed 20-0-0 weed killer is a fast-acting weed and feed solution that will help you deal with garden invaders and boost your garden’s health at the same time. The Spectracide weed killer is proven to be effective at eliminating major broadleaf weeds such as chickweed, dandelion, clover, plantain, knotweed, purslane, and clover among many others. This handy herbicide gets the job done without any complicated mixing with its handy QuickFlip sprayer.

To obtain the best possible results, we find that spraying the Spectracide weed and grass killer when the target weed is in its prime growing season is best.

Best Budget Pick: Roundup Weed and Grass Killer

Reasons to Buy

  • Kills the most resilient grasses and weeds fast
  • Rainproof in about 10 minutes
  • Premixed, Ready-to-Use formula
  • Evident results in less than 3 hours

The Roundup Weed and Grass Killer is our best budget pick because of its potency, size, and pre-mixed, ready-to-use formula. It also comes with a handy sprayer wand for easier application. You can use it in or around mulched beds, flowerbeds, veggie gardens, tree rings, as well as patios, walkways, and driveways. For its price, features, and effectiveness, this budget weed killer can’t be beat.

How to Pick The Best Weed Killer According to Your Specific Needs

There’s a dizzying array of weed killer options that all claim to be the best weed killer out there. However, how do you know exactly which one is really the best at getting rid of the weeds in your beloved garden? In order to make a more informed decision, you will have to first get friendly with the weeds invading your property and answer these vital questions.

What Kinds of Weeds are in Your Garden?

It’s imperative that you pick a weed killer that lists the specific weeds you want to eradicate on its label. But in order to do this, you first need to get yourself acquainted with the weeds that are trying to infest your garden to figure out what exactly they are. What do the weeds look like? Are they annual weeds such as foxtail or crabgrass that only grows in one season? Maybe you have more difficult to control and resilient ones like the perennial weeds dandelion, plantain or nutsedge that recur every single year? Essentially, the more you know about your weeds, the better your chances of killing them.

What’s Your Endgame—Kill or Prevent? Both?

Post-emergent weed killers target those that are already established and growing. Spraying them on the weeds will cause the plant system to die. Do note though that some post-emergent herbicides are non-selective, meaning that they don’t just kill weeds, but other plants as well. Pre-emergent weed killers, on the other hand, are used for preventing the growth of weeds. These are typically applied during spring when weeds begin to grow and are best used for annual, recurrent weeds.

How Much Weed Killer Do You Need?

If you are just trying to control weeds in a small area in your garden, you may want to opt for a ready-to-use, pre-mixed formula instead of a concentrate that you’ll need to mix. On the other hand, go with a concentrated formula if you are treating lots of weeds in a large area.

Main Takeaways

Once you have identified your weeds and answered the questions above, you can then choose from the best weed killer options we recommend above so you can choose one that will effectively kill the weeds in your garden. Don’t forget to handle it safely, follow all the directions on the label to a tee, and you’ll be on your way to a weed-free garden in no time.

So tell us, have you finally found the best weed killer for your garden from our list? Do let us know which one you picked below.

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Additional Resources:

Grounds Maintenance

National Pesticide Information Center

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